Influenza virus and the biology of broadly-neutralizing antibodies 2. This, Miller believes, will allow the IIDR to expand its foci in the years to come. Matthew S Miller Associate Professor, Biochemistry & Biomedical Sciences The Miller Laboratory studies diverse aspects of virus-host interactions. At the top of the Mcmaster . Wright, too, believes that Millers unique expertise will only serve to strengthen the IIDRs research profile. I have such a profound admiration and respect for Gerry and the way that he consistently rises the tide for others around him, says Miller, who joined McMaster in 2014 following the completion of his postdoctoral studies at the Icahn School of Medicine at Mount Sinai in New York. Dr. Matthew Miller is an assistant professor in the Department of Biochemistry and Biomedical Sciences at Mcmaster University, and principal investigator in The Institute for Infectious Diseases Research and The Mcmaster Immunology Research Centre. Matthew Miller Description: Portrait of Matthew Miller, Assistant Dean - Biochemistry Graduate Program, The Miller Laboratory, Associate . In the context of infections caused by viruses like influenza or SARS-CoV-2, it tends to be when the virus gets deep into the lung that it makes you really sick," explains Matthew Miller, a. Matthew S Miller Associate Professor, Department of Biochemistry and Biomedical Sciences, McMaster University Verified email at mcmaster.ca Virology Immunology Microbiology Infectious. . He went on to complete a PhD in the same department in the laboratories of Dr. Laura Hertel and Dr. Joe Mymryk, where he studied the molecular virology of DNA viruses, including human cytomegalovirus and human adenovirus. McMaster Biochemistry and Biomedical Sciences Society, Biomedical Discovery and Commercialization, Microbiology, Immunology and Drug Discovery, Biophotonics Laboratory for Microscopy and Molecular Imaging, Institute for Infectious Disease Research, Farncombe Family Digestive Health Research Institute, Centre for Metabolism, Obesity, and Diabetes Research, Postdoctoral Affairs and Research Training, Equipment, Room Booking & Supply Ordering. Matthew Miller MD, MSc, FRCPC Medicine, Nephrology Associate Professor Director, Nephrology Fellowship Program; Director, Medical Foundations 2; Medical Lead for Living Kidney Donor Program matthew.miller@medportal.ca MacExperts Amber Molnar Medicine, Nephrology Associate Professor 905-521-2100 ext. Matthew Miller, PhD Faculty. RESEARCH INTERESTS: Pandemics, influenza virus, coronavirus, vaccines, antivirals, virus/host interactions, neurodegenerative diseases, B cells, antibodies, McMaster Children's Hospital 1280 Main St WHSC - 4N59Hamilton, Ontario, CanadaL8S 4K1. Matthew McMaster. Matthew Miller, director of McMaster's Michael G. DeGroote Institute for Infectious Disease Research, says better strategies are needed to protect people from flu pandemics. We sit down with Dr. Miller to learn more about the global implications of these findings, what important steps his team at McMaster is taking next, and how the development of a novel universal flu vaccine . Cytomegalovirus Seropositivity in Older Adults Changes the T Cell Repertoire but Does Not Prevent Antibody or Cellular Responses to SARS-CoV-2 Vaccination. He works at Mark Finlay Architects. Oklahoma City Metropolitan Area. Malayalam Tagalog Bengali Vietnamese Malay Thai Korean Japanese Hindi. Distribution Associate at McMaster-Carr Lansdale, PA. Laura Szczepaniak (Wood) VP Travel Operations at . Copyright 2020 McMaster University. This Institute is very near and dear to my heart, and Im both grateful and excited for the opportunity ahead, he says. Jump to Sections of this page He attended Hobart College and received his master's from Syracuse University. Matthew Miller is an outstanding scientist and person, and his important research like that into next-generation COVID-19 vaccines will no doubt propel the IIDR to new heights, says Wright, who stepped down from his post at the IIDR to focus on establishing Canadas Global Nexus for Pandemics and Biological Threats. Matthew Miller Associate Professor, Medicine Contact Information EMAIL: millemc Affiliations Faculty of Health Sciences, McMaster University Associate Professor, Medicine, Faculty of Health Sciences Scholarly Activity in McMaster Experts Co-author Network Scholarly Activity Contact View All selected scholarly activity academic article 1280 Main Street West, Room 2235 | Hamilton, Ontario | L8S 4L8. McMaster Design Agency. Executed projects for large . Dr. Matthew Miller Far from suffering any negative consequences from this outrageous statement, which was literally a call for rigid social isolation of the unjabbed, Miller is still being. As an independent investigator, my expertise is primarily in the area of viral. Every year, the Ontario government publishes its annual Sunshine List of public sector servants with six-figure salaries. 22387. "Matthew Miller is an outstanding scientist and person, and his important research like that into next-generation COVID-19 vaccines will no doubt propel the IIDR to new heights," says Wright, who stepped down from his post at the IIDR to focus on establishing Canada's Global Nexus for Pandemics and Biological Threats. In his most recent publication, infectious disease expert Dr. Matthew Miller and colleagues find that being born during influenza pandemics enhances the risk of death during later pandemics. 2018 Ontario Sunshine List: Mcmaster University Top Earners. (Photo by Matt Clarke/McMaster University). Abnormal inflammation is a signature of many neurodegenerative diseases, yet the way in which inflammation contributes to the pathology of these diseases is poorly defined. Dr. Millers interest in infectious diseases and immunology began during his undergraduate education in the BMSc program at the University of Western Ontario, where he completed an Honors Specialization in Microbiology and Immunology. 22387 mmiller@mcmaster.ca Highly motivated graduate students and postdoctoral fellows are encouraged to apply by email - with CV and transcript (s) attached. HERE are many translated example sentences containing "DR MATTHEW MILLER" - french-english translations and search engine for french translations. All rights Reserved. His mentorship has been so important for me, and I hope that I can embody many of the same leadership qualities that he has throughout his run as Director.. The groom is a son of Sue and Andy McMaster of Darien. Considered the holy grail of flu prevention, a universal or durable vaccine promises to do away with the annual guess work of trying to produce a flu vaccine successfully targets all the prevailing and quickly mutating strains of influenza each year. Matthew Miller, senior author of the paper, an assistant professor of biochemistry and biomedical sciences at McMaster University, and senior researcher with its Michael G. DeGroote Institute of . Tel: 905-525-9140 ext. AMR will always be a central priority for the IIDR, not only because it is one of the most important global health challenges of our time, but also because the international profile of the IIDR has, to a large extent, been built on the back of our success in AMR research, he explains. Matthew Miller Research in the Miller Laboratory is divided into three main areas of focus: Innate & Adaptive Immunity Upon infection, both the innate and adaptive immune system is mobilized to protect the host from virus-mediated pathologies. During his PhD studies, Dr. Miller was awarded a highly competitive Frederick Banting and Charles Best CIHR Doctoral Award. Jan 2021 - Present1 year 11 months. As a postdoctoral fellow, I trained in viral immunology, focused primarily on pandemic influenza and vaccinology. For Miller, an associate professor of Biochemistry & Biomedical Sciences, being named Wrights successor is the honour of a lifetime. The Miller Laboratory is studying strategies to prevent vaccine resistance by targeting conserved features of the . By Matthew Miller, BS, MBA Mar 26, 2017. Photography: Bruce Plotkin Photography Jeanne Ladue with Lindsey Floral centerpiece Indeed, where Wrights focus has largely orbited around antimicrobial resistance (AMR), Miller specializes in viral pandemics, including those caused by influenza and SARS-CoV-2. Matt's passion for architectural design emerged while attending Hobart College where he pursued a major in architectural studies and a minor in art history. Dr. Miller also discovered an unexpected role for Senataxin a protein involved in several neurodegenerative disorders, including ALS in regulating the antiviral response. This work has been instrumental in the ongoing development of a universal influenza virus vaccine and remains an active area of study in the Miller Lab. McMaster University assistant professor Matthew Miller. DeGroote Institute for. Influenza A virus (IAV) presents a particularly formidable challenge to the adaptive immune system. 33787 molnaa1@mcmaster.ca MacExperts Through the Nexus, Wright will remain a key collaborator for the IIDR a partnership Miller believes will create immense opportunity for the Institute. While Miller says he and Wright already share lot of similarities in style and approach, he acknowledges that their research interests differ considerably. That said, we cannot rest on our laurels. All rights Reserved. As a small liberal arts college, Matt was able to develop a strong architectural skill set while also pursuing a variety of other subjects linked closely to the . He is a member of the Republican Party.. McMaster worked for U.S. senator Strom Thurmond, in private practice, and as a federal prosecutor.Appointed United States attorney for the District of South Carolina by President Ronald Reagan in 1981 . High-dose dexamethasone compared with prednisone for previously untreated primary immune thrombocytopenia: a systematic review and meta-analysis. DEAD MAN DANCING By Matthew Miller, BS, MBA . In the context of infections caused by viruses like influenza or SARS-CoV-2, it tends to be when the virus gets deep into the lung that it makes you really sick," explains Matthew Miller, a co-author of the study who holds the Canada Research Chair in Viral Pandemics at McMaster University. The Faculty of Health Sciences is committed to providing a website that is accessible to the widest possible audience. According to the document, Mcmaster University's 1,203 staffers made the Sunshine List, earning total compensation of in 2017. Dr. Miller recently discussed his work on the Bill Kelly Show, CHML 900 Global Radio. The IIDR members are from three faculties and eight departments at McMaster University. Regulation of humoral immunity 3. These studies were supported, in part, by a prestigious CIHR Postdoctoral Research Award. The virus has specific properties that allow it to cause seasonal epidemics and periodic pandemics, which leads to current- generation IAV vaccines having to be administered seasonally, while providing optimal protection against only a very limited number of IAV strains. More than 400 graduate students, post-doctoral and clinical fellows research various programs funded by provinci . ALS Influenza Virus McMaster University, Hamilton, Ontario, Canada Date Created: Thu Jun 24 00:00:00 EDT 2021 . Matthew Miller, PhD. All rights Reserved. Copyright 2020 McMaster University. The Miller group is focused on understanding the immunobiology of these antibodies, how they are elicited, and how they may be useful for the generation of universal influenza virus vaccines and therapeutics. This relationship between infection-inflammation-neurodegeneration is an area of active investigation by the Miller Lab. This Q and A was originally posted as an "Ask Me Anything" series on McMaster's Instagram account. MDCL 2324 McMaster University. Sustained Delivery of a Monoclonal Antibody against SARS-CoV-2 by Microencapsulated Cells: A Proof-of-Concept Study, Hemagglutinin stalk-binding antibodies enhance effectiveness of neuraminidase inhibitors against influenza via Fc-dependent effector functions, A Universal DNA Aptamer that Recognizes Spike Proteins of Diverse SARSCoV2 Variants of Concern, Front Cover: A Universal DNA Aptamer that Recognizes Spike Proteins of Diverse SARSCoV2 Variants of Concern (Chem. Dr. Miller is an Associate Professor in the Department of Biochemistry and Biomedical Sciences at McMaster University and Scientific Director of the Michael G. DeGroote Institute for Infectious Diseases Research. Repeated Seasonal Influenza Vaccination: How Much Is Too Much of a Good Thing? J. Mortality trends during influenza virus pandemics Startup creative design agency committed to bringing bright ideas to life. The couple now call Norwalk their home. McMaster University 905-525-9140 ext. 1280 Main Street West, Room 2235 | Hamilton, Ontario | L8S 4L8. The Miller Lab focuses on understanding both the protective and harmful qualities of immune responses essential information for developing novel vaccines and therapeutics. If there is an accessibility issue with this website, please contact us at fhsaoda@mcmaster.ca. Upon infection, both the innate and adaptive immune system is mobilized to protect the host from virus-mediated pathologies. Current areas of focus include: Associate Professor, Biochemistry & Biomedical Sciences, McMaster Immunology Research Centre (MIRC), Michael G. DeGroote Institute for Infectious Disease Research (IIDR). During his time in New York, Dr. Millers research focused on characterizing the innate and adaptive immune responses to viral infection. Associate Professor, Department of Biochemistry and Biomedical Sciences Assistant Dean and Associate Chair, Biochemistry Graduate Program. Dawn Bowdish, Andrew McArthur, Matthew Miller, Karen Mossman, and Gerry Wright, members of the MGDII College of Health Inventors, have been awarded funding to continue COVID-19 research. While it is important for the Institute to maintain its own unique priorities, the landscape at McMaster has shifted toward having a stronger strategic focus on infectious diseases, which will open new doors for the IIDR.. Dr. Miller is an Associate Professor in the Department of Biochemistry and Biomedical Sciences at McMaster University. Current areas of focus include: 1. However, a new class of antibodies has recently been discovered which is capable of providing much more broad protection across multiple IAV subtypes. Eur. Dr. Matthew Miller In a recent interview, the Ontario Science Centre claimed that "universal flu vaccine" research being undertaken in Dr. Matthew Miller 's lab was one of the most under-rated scientific achievements of 2017. We asked Matthew Miller, associate professor, biochemistry and biomedical sciences, to answer questions from our community about COVID-19, pandemics, and infectious diseases in general. Part of being an innovative and world-leading institute is evolving and being forward-looking, and I believe that my experience studying virology and viral pandemics will allow us to advance new priority research areas for the Institute going forward, as we continue to support our core strength in AMR.. Copyright 2020 McMaster University. As a successful young scientist in the field of immunology, he is pushing the frontiers of . Specifically, Dr. Millers work helped to define how broadly-neutralizing antibodies against influenza A virus are generated and function in humans. Research in the Miller Laboratory is divided into three main areas of focus: Innate & Adaptive Immunity He was also honored to receive the Dr. John Robinson Graduate Scholarship, the John A. Thomas Award and the Stephen D. Poland Award from the Department of Microbiology and Immunology at Western University. Henry Dargan McMaster (born May 27, 1947) is an American politician and attorney serving as the 117th governor of South Carolina since January 24, 2017. Matthew Miller - Director, M.G.DeGroote Institute for Infectious Disease Research - McMaster University | LinkedIn Join now Sign in Matthew Miller Director, M.G. Matthew Miller PhD Faculty Full Biography Associate Professor, Scientific Director, Michael G. DeGroote Institute for Infectious Disease Research (IIDR) Scientific Director, Michael G. DeGroote Institute for Infectious Disease Research (IIDR) Biochemistry and Biomedical Sciences, McMaster Immunology Research Centre Original article posted on brighterworld.mcmaster.ca on November 6, 2020 Dr. Canadian researcher Matthew Miller believes that could happen with a decade. One of the really exciting opportunities for the IIDR going forward is its association with Canadas Global Nexus, Miller explains. Matthew Miller, Faculty of Health Sciences, explains the UK variant of COVID-19 and the effectiveness of vaccines against other mutations of the virus. (McMaster University) Miller said their vaccine, which is a broad spectrum antibody found in the lung which attaches to the virus at a. Miller, a long-time member of the IIDR, transitioned into his new role on July 18, 2022, marking the first time that the Institute has been under new leadership since Gerry Wright served as its inaugural director upon its establishment by an endowment from Michael DeGroote in 2007. Call Matthew D. McMaster, LLC now at 800-890-3981 to learn more about Lawyer in Marietta, GA. Being named scientific director has been a full-circle experience for Miller, who notes that it was actually the opportunity to work within the IIDR that attracted him to working at McMaster all those years ago. Matthew Miller has been named Scientific Director of the Michael G. DeGroote Institute for Infectious Disease Research (IIDR) at McMaster University. It is bittersweet moving on, but knowing that Matthew is stepping in fills me with great confidence and great pride.. BY Michelle Donovan August 16, 2022 Health & Medicine Infectious Disease The Miller Laboratory studies diverse aspects of virus-host interactions. After completing his PhD, Dr. Miller moved to the Icahn School of Medicine at Mount Sinai (Mount Sinai) in New York, NY, to pursue postdoctoral studies in the laboratory of Dr. Peter Palese. Rapid Design of a Bait Capture Platform for Culture- and Amplification-Free Next-Generation Sequencing of SARS-CoV-2, Thermal Stabilization of Viral Vaccines in Low-Cost Sugar Films, Correction to: Determinants of Influenza Mortality Trends: Age-Period-Cohort Analysis of Influenza Mortality in the United States, 19592016, Determinants of Influenza Mortality Trends: Age-Period-Cohort Analysis of Influenza Mortality in the United States, 19592016, Comparative Immunogenicity of the 20142015 Northern Hemisphere Trivalent IIV and LAIV against Influenza A Viruses in Children, Excipient selection for thermally stable enveloped and non-enveloped viral vaccine platforms in dry powders, Original Antigenic Sin: How First Exposure Shapes Lifelong AntiInfluenza Virus Immune Responses, Reporting and evaluating influenza virus surveillance data: An argument for incidence by single year of age, Reviewing the evidence for viruses as environmental risk factors for ALS: A new perspective, Gnothi Seauton: Leveraging the Host Response to Improve Influenza Virus Vaccine Efficacy, Pandemic Paradox: Early Life H2N2 Pandemic Influenza Infection Enhanced Susceptibility to Death during the 2009 H1N1 Pandemic, Alveolar macrophages are critical for broadly-reactive antibody-mediated protection against influenza A virus in mice, Regulation of kynurenine biosynthesis during influenza virus infection, Abnormal regulation of the antiviral response in neurological/neurodegenerative diseases, Broadly Neutralizing Hemagglutinin Stalk-Specific Antibodies Induce Potent Phagocytosis of Immune Complexes by Neutrophils in an Fc-Dependent Manner, Epitope specificity plays a critical role in regulating antibody-dependent cell-mediated cytotoxicity against influenza A virus, Optimal activation of Fc-mediated effector functions by influenza virus hemagglutinin antibodies requires two points of contact, Hemagglutinin Stalk Immunity Reduces Influenza Virus Replication and Transmission in Ferrets, CARMA3 Is a Host Factor Regulating the Balance of Inflammatory and Antiviral Responses against Viral Infection, Measuring the neutralization potency of influenza A virus hemagglutinin stalk/stem-binding antibodies in polyclonal preparations by microneutralization assay, Senataxin suppresses the antiviral transcriptional response and controls viral biogenesis, Broadly Neutralizing Anti-Influenza Virus Antibodies: Enhancement of Neutralizing Potency in Polyclonal Mixtures and IgA Backbones, Is Antigenic Sin Always Original? Re-examining the Evidence Regarding Circulation of a Human H1 Influenza Virus Immediately Prior to the 1918 Spanish Flu, Induction of broadly cross-reactive antibody responses to the influenza HA stem region following H5N1 vaccination in humans, Peering into the Crystal Ball: Influenza Pandemics and Vaccine Efficacy, Assessment of Influenza Virus Hemagglutinin Stalk-Based Immunity in Ferrets, Neutralizing Antibodies Against Previously Encountered Influenza Virus Strains Increase over Time: A Longitudinal Analysis, Serum- and Glucocorticoid-Regulated Kinase 1 Is Required for Nuclear Export of the Ribonucleoprotein of Influenza A Virus, 1976 and 2009 H1N1 Influenza Virus Vaccines Boost Anti-Hemagglutinin Stalk Antibodies in Humans, Age-Specific Mortality During the 1918 Influenza Pandemic: Unravelling the Mystery of High Young Adult Mortality, Characterization of the 55-Residue Protein Encoded by the 9S E1A mRNA of Species C Adenovirus, Adenovirus E1A Directly Targets the E2F/DP-1 Complex, An unhealthy relationship: viral manipulation of the nuclear receptor superfamily, RASCAL Is a New Human Cytomegalovirus-Encoded Protein That Localizes to the Nuclear Lamina and in Cytoplasmic Vesicles at Late Times Postinfection, Onset of Human Cytomegalovirus Replication in Fibroblasts Requires the Presence of an Intact Vimentin Cytoskeleton, Human cytomegalovirus US9 protein contains an N-terminal signal sequence and a C-terminal mitochondrial localization domain, and does not alter cellular sensitivity to apoptosis, Antibody idiotype plays a critical role in regulating antibody-dependent cell-mediated cytotoxicity (ADCC) against influenza A virus, Fc-dependent effector functions of neutrophils induced by hemagglutinin stalk-specific antibodies, Road to Biomedical Discovery - BIOMEDDC 3A03, Drug Discovery and Development - BIOMEDDC 3B06B, Drug Discovery and Development - BIOMEDDC 3B06A, Independent Study in Medical Sciences - MEDSCI 799. Translations in context of "DR MATTHEW MILLER" in french-english. The Miller Lab is working to understand the role of inflammation in the etiology of neurodegenerative diseases, with a specific focus on its role in amyotrophic lateral sclerosis (ALS). Matthew Miller Dr. Miller is an Associate Professor in the Department of Biochemistry and Biomedical Sciences at McMaster University and Scientific Director of the Michael G. DeGroote Institute for Infectious Diseases Research. 15/2022), Inactivated and live-attenuated seasonal influenza vaccines boost broadly neutralizing antibodies in children, Gut microbiota-based vaccination engages innate immunity to improve blood glucose control in obese mice, Lasting Changes to Circulating Leukocytes in People with Mild SARS-CoV-2 Infections, HighAffinity Dimeric Aptamers Enable the Rapid Electrochemical Detection of WildType and B.1.1.7 SARSCoV2 in Unprocessed Saliva, Probe design for simultaneous, targeted capture of diverse metagenomic targets, Antibody Responses 3-5 Months Post-Vaccination with mRNA-1273 or BNT163b2 in Nursing Home Residents, Effects of repeated vaccination and vaccine formulation on the induction of broadly neutralizing antibody responses against influenza A virus in children, Diverse high-affinity DNA aptamers for wild-type and B.1.1.7 SARS-CoV-2 spike proteins from a pre-structured DNA library, IgA potentiates NETosis in response to viral infection, Neutrophils and Influenza: A Thin Line between Helpful and Harmful, A liposome-displayed hemagglutinin vaccine platform protects mice and ferrets from heterologous influenza virus challenge, Covalent Stabilization of Antibody Recruitment Enhances Immune Recognition of Cancer Targets, Experimental and natural evidence of SARS-CoV-2-infection-induced activation of type I interferon responses, Characteristics of Anti-SARS-CoV-2 Antibodies in Recovered COVID-19 Subjects, Engineered Nanoparticle Applications for Recombinant Influenza Vaccines, Predicting the recombination potential of severe acute respiratory syndrome coronavirus 2 and Middle East respiratory syndrome coronavirus, Age-Specific Incidence of Influenza A Responds to Change in Virus Subtype Dominance, Cross-Sectional Evaluation of Humoral Responses against SARS-CoV-2 Spike, Immunological considerations for COVID-19 vaccine strategies, Bat Influenza Viruses: Making a Double Agent of MHC Class II, Isolation, Sequence, Infectivity, and Replication Kinetics of Severe Acute Respiratory Syndrome Coronavirus 2. 1280 Main Street West, Room 2235 | Hamilton, Ontario | L8S 4L8. 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