In this episode, I am joined by Dr. David Sinclair, tenured Professor of Genetics at Harvard Medical School and an expert researcher in the field of longevity. The sensor is waterproof and comfortable to wear. Last medically reviewed on January 29, 2022 10 sources collapsed David A. Sinclair mainly investigates NAD+ kinase, Cell biology, Internal . By analysing decades of research and running thousands of original experiments on herself wearing a continuous glucose monitor, she has distilled 10 simple and surprising hacks that can be easily incorporated into everyday life. Dr. David Sinclair has revolutionized the way that people view aging. . Oxidative phosphorylation and Cell nucleus is closely connected to Glucose homeostasis in his research, which is encompassed under the umbrella topic of Sirtuin 1. . "Theoretically, we can detect all of them at the same time, but that would require a different sensor design," added Yin. 4/ Cortisol. David A. Sinclair, PhD, AO . Our Members are using personalized data to discover their optimal diet, control their weight, and reduce long-term . Thinking about monitor your glucose levels in an efficient way? Dr. David Sinclair is a professor of genetics and co-director of Harvard Medical School's Paul F. Glenn Center for Biology of Aging Research. David Sinclair, Harvard University, just said that we can be immortal. Plus I'll be looking into getting a continuous glucose monitor in the near future as well. New episodes will be released every Wednesday morning of both January and . 1,800. They share the latest experimental and clinical data for NAD boosters, resveratrol, fisetin, quercetin, rapamycin, spermidine, metformin, and berberine. David Sinclair Discusses His 2022 Supplement Protocol: 1g Resveratrol, 1g NNM, 1g Spermidine, 800mg Metformin, 0.5g Quercetin, & 0.5g Fisetin . In this episode, Dr. David Sinclair and co-host Matthew LaPlante discuss how frequently we should eat, what food we should avoid, and what food we should pursue. Measure your biological age with these 5 research-backed, free, at-home tests. As such, markers of liver health can be used to monitor whether or not methyl donor depletion is causing problems in the body. Guidelines for the use and interpretation of assays for monitoring autophagy (3242 citations) . Blood lactate was measured before and immediately after treadmill exercise (30 min at 15 m/min) by tail bleed using a commercially available lactate meter. 2/ Heart. David Mendosa reviewed some reviews on home blood glucose monitor accuracy and reproducibility.. Harriet Hall, M.D., reviewed his 2019 anti-aging book at Science-Based Medicine. Can't wait to get your bloodwork? The Biology of Reversing Aging with Dr. David Sinclair and Dr. Andrew Huberman. Five metrics which Dr. Sinclair would like to monitor given only five, he then added the sixth: 1) glucose , 2) heart function, 3) inflammation (CRP: C-Reactive Protein), 4) cortisol (stress levels), 5) lactate (if body is able to deal with exercise), 6) blood oxygen (making sure get hypoxic) to stimulate hormesis… With societal adoption data . Employer Program; . We wrote about the best blood tests for longevity here. Employer Program; . Professor Sinclair uses a continuous glucose monitor (CGM) to track how the foods he eats increase his blood sugar levels. In this episode, Dr. David Sinclair and co-host Matthew LaPlante discuss how frequently we should eat, what food we should avoid, and what food we should pursue. . David Sinclair: Yes, I am. NIH. Blood Glucose Meter; Dr. Casey Means . R21HG011850 (SINCLAIR, DAVID A.) ABOUT DR. DAVID SINCLAIR. Best for blood-free readings: FreeStyle Libre. Tagmentation-based Indexing for Methylation Sequencing as a novel method of high-throughput methylation clock measurement. He also wears smart devices - such as the Oura Ring and the Levels Continuous Glucose Monitoring patch. Reply. 3/ Inflammation. 1/ Glucose. Most accurate continuous glucose monitor (CGM): Dexcom G6. Best for detailed glucose data: Guardian Connect . Harvard Professor and Longevity Expert Partners with Levels to Solve Metabolic Health Crisis NEW YORK, October 12, 2021 -- ( BUSINESS WIRE )-- Levels, the first biosensor system to give real-time. We do not know the relevance to disease of a blood glucose level 140 mg/dL immediately after a glucose load. #4. David Sinclair, Ph.D. is a professor of genetics at Harvard Medical School. I'm surrounded by these charlatan types. Published on September 11, 2019. . We discuss fasting and supplementation with . Levels advisor and author of Lifespan, David Sinclair, sat down with Levels Chief Medical Officer, Casey Means, Head of Growth, Ben Grynol and Head of Research & Development, Taylor Sittler, during our Levels Book Club on December 16, 2021 to take questions from our team and our members. Biomarkers you should consider monitoring now. 859-721-1414 [email protected] 0 Items. We Used a Continuous Glucose Monitor CGM for 2 Weeks - CGM Experiment Results #306 How High Blood Sugar Wrecks Your Health . . David Sinclair is a professor in the Department of Genetics and co-director of the Paul F. Glenn Center for the Biology of Aging at Harvard Medical School, w. His biomarker list is summarized below. 00:33:26 Continuous Glucose Monitors 00:34:24 Genetics Influence How an Intervention Affects Aging 00:36:51 A Trick for Fasting: Filling your Body with Fluids Here's his current anti-aging regimen as outlined by Dr Hall: He makes no recommendations for others except "Eat fewer calories", "Don't sweat the small stuff", and "Exercise". Sinclair explains that your liver will start making glucose at a steady level after a few weeks, so there won't be large spikes of insulin that put you in a glucose deficit and make you tired. Lifespan: Why We Age—and Why We Don't Have To by David Sinclair (with Matthew LaPlante, 2019) is a book that will change your perspective on life, death, and aging. He was motivated by an article in Consumer Reports. Using a transgenic mouse system for inducible creation of DSBs, he revealed that loss of epigenetic structures, an accumulation of epigenetic noise and increased predicted DNA methylation changes increase with age and DNA . Home; Services. David Sinclair and Anti-Aging Supplements. Sep 17, 2021 - Aug 31, 2023. Frame aging as a disease and a world . Jackie Cooperman. Yet a blood glucose level of 140 mg/dL two hours after a glucose load means something drastically different from a blood glucose level of 140 mg/dL immediately after a glucose load. Like many people, his diet varies and he likes to experiment with different ones. But in the process it's breaking down your muscle to make that glucose. David Sinclair's LIFESPAN Part 2; The Information Theory of Aging: David Sinclair's Book LIFESPAN (Part 1) Longevity: Diets vs. Dr. Sinclair is also the author of the book Lifespan: Why We Age & Why We Don't Have To, and the host of the Lifespan Podcast, which launches January 5, 2022. . The second is much more variable than first. It hasn't been studied yet. Dr. Sinclair is also the author of the book Lifespan: Why We Age & Why We Don't Have To, and the host of the Lifespan Podcast, which launches January 5, 2022. Chris Kresser: I see you're wearing a CGM [continuous glucose monitor]. Capture real-time glucose readings with one-second painless scans of a . 0:36 . Blood Glucose Monitor Meter, Diabetes Testing Kit [2020 Upgrade] Blood Sugar Tester with 25 Test Strips and 25 Lancets - for UK Diabetics in mmol/L by Exactive EQ. In this episode, I am joined by Dr. David Sinclair, tenured Professor of Genetics at Harvard Medical School and an expert researcher in the field of longevity. R21DE027490 (SINCLAIR, DAVID A.) I'm surrounded by these charlatan types. 00:33:26 Continuous Glucose Monitors 00:34:24 Genetics Influence How an Intervention Affects Aging 00:36:51 A Trick for Fasting: Filling your Body with Fluids It translates the glucose measurements into dynamic data to show glucose direction and rate of change on your smartphone. Continuous glucose monitor: worn in the arm and useful for learning what spikes blood sugar and how various foods impact blood sugar Continuous glucose monitors currently require a prescription but are worth talking to your physician 0:34:24 Genetics Influence How an Intervention Affects Aging. David Sinclair's Current Diet and Food Preferences. Reading David Sinclair's book has made me more hopeful than ever that 200 might be possible. Sep 1, 2018 - Aug 31, 2020. NEW YORK, October 12, 2021--Levels, the first biosensor system to give real-time feedback on nutrition and lifestyle, today announced that leading longevity scientist Dr. David Sinclair has joined the company as a Levels Advisor. November 19, 2021. nightengale I wish we could do this. By analysing decades of research and running thousands of original experiments on herself wearing a continuous glucose monitor, she has distilled 10 simple and surprising hacks that can be easily incorporated into everyday life. #3. The top five biomarkers for monitoring health . . But you can't know your insulin sensitivity unless you're measuring glucose, have a glucose monitor on your arm. Sinclair is a Professor in the Department of Genetics and the co-Director of the Paul F. Glenn Center for Biology of Aging Research at Harvard Medical School. November 19, 2021. nightengale I wish we could do this. . And we discuss the key blood markers everyone should monitor to determine your biological versus chronological age. 00:35:56 Blood . Drink at least 1.5 of liters per day: that's 8 glasses per day. . He hosts the popular podcast The Tim Ferriss Show. It will utterly crash your glucose levels and land you in the ER with hypoglycemia. NEW YORK-(BUSINESS WIRE)-Levels, the first biosensor system to give real-time feedback on nutrition and lifestyle, today announced that leading longevity scientist Dr. David Sinclair has joined the company as a Levels Advisor.Dr. was recruited to Harvard Medical School where he has been teaching aging biology and translational medicine for aging for the past 16 years . Dr. Sinclair is also the author of the book Lifespan: Why We Age & Why We Don't Have To, and the host of the Lifespan Podcast, which launches January 5, 2022. One of the most prominent longevity researchers, David Sinclair PhD recently disclosed his top five biomarkers for monitoring health. Lifespan with Dr. David Sinclair is a new podcast from world renowned aging research doctor, David Sinclair, Ph.D. Dr. Sinclair is a professor of genetics and co-director of Harvard Medical School's Center for Biology of Aging Research. Professor latest from david sinclair uses a continuous glucose monitor ( CGM ) to track the!, A.O contract to bring a dedicated fiber line to the forum servers benefits with a 12 % reduction. He is known for his research on aging with a focus on epigenetics, and has been at the forefront of the biohacking world's conversation on anti-aging and longevity for . 5/ Lactate + Blood Oxygen They discuss the science behind how a "low energy state," which can be induced by a period of fasting, combats aging and promotes health. Professor of Genetics and co-Director of the Paul F. Glenn Center for Biology of Aging Research, Harvard Medical School; Author of Lifespan . The last time I looked into this, I found that a device could receive FDA approval if it could measure accuracy to within 20% of the actual blood sugar value as determined by a laboratory machine. Time-restricted feeding, which involves not eating for at least 16 hours within 24 hours, is Dr. Sinclair's preferred fasting method. In this episode, Dr. David Sinclair and co-host Matthew LaPlante discuss how frequently we should eat, what food we should avoid, and what food we should pursue. It's already happening for diabetics, but for healthy people it will remain niche. As a scientist and pioneer in genetics and longevity research, he's been listed by TIME as one of the "100 Most Influential People in the World," has received more than 35 awards and honors, and is currently working as a professor in the Department of Genetics and co-director . Talk with your doctor about your concerns with blood glucose monitoring, and whether a noninvasive meter may better fit your needs. A Continuous Glucose Monitor (CGM) is a small sensor used to measure blood sugar levels in the body throughout the day. 0:33:26 Continuous Glucose Monitors. He shows me the ring he wears that monitors his heart rate, body temperature and movements. About Levels. Thinking about monitor your glucose levels in an efficient way? He's the co-director of the Paul F. Glenn Center for the Biology of Aging and has been a member of our scientific advisory board here at InsideTracker since the early days of the company. Longest lasting CGM sensor: Eversense. And beyond telling you how not to die, in a perfect radio voice, he will introduce you to some of the most productive, creative, and knowledgeable people on earth. Dr. David Sinclair is a professor of genetics and co-director of Harvard Medical School's Paul F. Glenn Center for Biology of Aging Research. The Euphoria and Dune star attended the Gala was in 2019 images davidsinclairphoto.com. Drink lots of water. Sinclair's core thesis is that aging is a disease. 0.5-1.4 is healthy; above 2 is early insulin resistance . The current prototype of the patch is capable of measuring three parameters at once, one from each sensor: blood pressure, glucose and either lactate, alcohol, or caffeine. The first just shows you a 3-month (ish) average. The best thing you can do diet was is to limit sugar and glucose spikes. 4/ Cortisol. Sam Harris . Season 1 will be 8 episodes in total and will launch on Wednesday, January 5, 2022. This bucks conventional wisdom that views aging as an inevitable part of life. In this episode, Dr. Huberman is joined by Dr. David Sinclair, tenured Professor of Genetics at Harvard Medical School and an expert researcher in the field of longevity. Don't take whey protein, testosterone or growth hormone. Role: Principal Investigator. In this interview, we discuss the cellular and molecular mechanisms of aging and what we all can do to slow or reverse the aging process. . " So the first measures sugar bound to blood cells. 2. Monitor insulin sensitivity: Measure fasting insulin, fasting glucose (a lab test), then go to "Calculate HOMA-IR score" website, plug in fasting glucose, fasting insulin and site calculates HOMA-IR score. "Peter Attia is one of the most interesting doctors you will ever meet. It translates the glucose measurements into dynamic data to show glucose direction and rate of change on your smartphone. I have not given up . 0:36:51 A Trick for Fasting: Filling your Body with Fluids . Sometimes, you really are talking to the smartest person in the room. . The sensor is waterproof and comfortable to wear. . 859-721-1414 [email protected] 0 Items. 3/ Inflammation. The sensor measures your interstitial glucose level, which is the glucose found in the fluid between the cells. With the recent approval by the FDA, the FreeStyle Libre system can be used as a replacement for BGM. Dr. Sinclair is a Professor in the Department of Genetics and the co-Director of the Paul F. Glenn Center for Biology of Aging Research at Harvard Medical School. 00:00:00 Dr. David Sinclair, Harvard Medical School. This podcast talks about how to slow down aging and the latest anti-aging research with Dr David Sinclair. Levels helps you see how food affects your health. (3:18) - The concept of death (06:22) - Extending youth vs old age (08:11) - Health needs to start young . The Drive is one of my favorite podcasts.". Examples of continuous glucose monitors are FreeStyle Libre or Levels (not sponsored). Dr. David Sinclair: "Sure, well, there was a study, again, by Shin Imai, my good friend at Washington University in St. Louis that showed that improves — remember this insulin sensitivity, which is a good thing. In this week's episode, Dr. David Sinclair and co-host Matthew LaPlante zero in on drugs and supplements that have been reported to combat aspects of aging. This is just the beginning of the way in which we will monitor ourselves as companies read our genomes and monitor our glucose, the oxygen levels in our blood, vitamin balance and . Accu-Check Performa Tablet Strips (Pack of 50) 4.6 out of 5 stars. . David Sinclair's LIFESPAN Part 2; The Information Theory of Aging: David Sinclair's Book LIFESPAN (Part 1) Longevity: Diets vs. The sensor gets applied to the back of the upper arm. David Sinclair is an Australian biologist who is a professor of genetics and co-director of the Paul F. Glenn Center for Biology of Aging Research at Harvard Medical School. 2/ Heart. mint), citron or NOVOS Core to add taste to your water. His biomarker list is summarized below. Well, there's no . That works great. David Sinclair, Harvard, USA, showed that DSBs may drive age-dependent epigenetic alterations and loss of cellular identity. Pills; In this interview, we discuss the cellular and molecular mechanisms . This type of information can help you personalize your diet and get concrete, meaningful feedback on your health like never before. Blood glucose, lactate and VEGF . He also does regular blood tests to track his health. Dr. David Sinclair shows which biomarkers he's tracking (using a company called InsideTracker) in this Instagram post. Its been shown to work best 20-30 min before meals. The second measures sugar in fluid between the cells. (≥ 16 Hours of Fasting) (0:33:26) Continuous Glucose Monitors (0:34:24) Genetics Influence How an Intervention . Biomarkers you should consider monitoring now. One of the most prominent longevity researchers, David Sinclair PhD recently disclosed his top five biomarkers for monitoring health. problems. [00:50:04.350] - Dr. David Sinclair. The top five biomarkers for monitoring health . . . - David Sinclair NAD+ is essential for: Sirtuin activation Metabolizing fatty acids/glucose ATP (energy) production (cells that have high energy demands, like activated immune cells, are thought to require even more NAD+) Activating DNA repair enzymes (specifically PARPs) As DNA damage accumulates, you need even more NAD+ - it's a vicious cycle! David Sinclair, professor of Genetics at Harvard personally takes . —DAVID SINCLAIR, Ph.D, Harvard Professor, TIME Magazine "100 most influential people in the world" and New York Times bestselling author of Lifespan "I hugely enjoyed reading this book; Jessie offers a detailed understanding of the problem which faces so many of us - how to balance our blood sugar levels - along with simple and accessible . Demolishes doctors who say stick-on glucose monitors are only useful for diabetics, the all-too-common "let patients get sick before we act" attitude that harms millions of Americans. With the FreeStyle Libre system, people with diabetes can: Self-apply the sensor, which is approximately the size of two stacked quarters, to the back of the upper arm. ASG: . Summary. You'll want to click through his links for details. Mice were fasted for 6 hrs and blood glucose levels were measured by tail bleed using a commercially available glucose meter. . 1 offer from £16.99. David Sinclair, Harvard Professor and NYT bestselling author of Lifespan 'This breakthrough book is a savvy, one . Season 1 will be 8 episodes in total and will launch on Wednesday, January 5, 2022. . 0:34:24 Genetics Influence How an Intervention Affects Aging. . The sensor gets applied to the back of the upper arm. Harvard researcher David Sinclair argues that aging is a disease that can be treated. A Continuous Glucose Monitor (CGM) is a small sensor used to measure blood sugar levels in the body throughout the day. Methylation is a particularly important process in the liver. And I've learned to rely on it, actually. 4.4 out of 5 stars. By leveraging biosensors like continuous glucose monitors (CGMs), Levels provides real-time feedback on how diet and lifestyle choices impact your metabolic health. If you're interested in reversing aging, watch Dr. Andrew Huberman interview renown anti-aging expert Dr. David Sinclair, who details his life extension protocols that has reduced his biological age by nearly 20 years. With a Levels continuous glucose monitor (CGM), you can understand your metabolic flexibility by seeing your body's glucose levels before, during and after a workout. Sinclair is a Professor in the Department of Genetics and the co-Director of the Paul F. Glenn Center for Biology of Aging Research at Harvard Medical School. Drink green tea, white tea, ginger tea or coffee (yes, coffee can reduce the risk of various aging-related diseases). Not the super-duper one, just the one that you scan with your iPhone and get a reading. . David Sinclair has expressed reservation of this drug due to risks. Home; Services. Add spices (e.g. Check out this week's blog. 0:33:26 Continuous Glucose Monitors. Check out this week's blog. In this episode, Dr. David Sinclair and co-host Matthew LaPlante discuss how frequently we should eat, what food we should avoid, and what food we should pursue. Dr. Sinclair is also the author of the book Lifespan: Why We Age & Why We Don't Have To, and the host of the Lifespan Podcast, which launches January 5, 2022. (0:33:26) Continuous Glucose Monitors (0:34:24) Genetics Influence How an Intervention Affects Aging (0:36:51) A Trick for Fasting: Filling your Body with Fluids . David Sinclair, Harvard Professor and NYT bestselling author of * Lifespan * 'This breakthrough book is a savvy . Welcome to Lifespan with Dr. David Sinclair. . Levels is an app that syncs with a continuous glucose monitor, which they provide and interprets your glucose data for you. Previously, his diet was as follows: He skipped one meal a day (often lunch) or just made that meal very . CONCLUSION Dr. David Sinclair is a professor of genetics and co-director of Harvard Medical School's Paul F. Glenn Center for Biology of Aging Research. They also walk through research that points to the benefits of a mostly plant-based diet for . David A. Sinclair, Ph.D., A.O. Dr. Sinclair has been at the forefront of the latest discoveries in understanding why we age and how to slow its effects. Can You Slow Down Aging "Aging is a disease and we can cure it," says David Sinclair in his book Lifespan. It's like a video game that you play with your body. David Sinclair: Best article @PeterAttiaMD has written. 1/ Glucose. 3 offers from £17.90. How long do you think it will be before most people have things like continuous glucose monitors? Pills; It's also part of the game. 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